ACTIVE+
- EVALUATION OF THE DIFFERENTIAL IMPACT OF VENETOCLAX AND VENETOCLAX-BASED COMBINATION REGIMENS ON PRE-EXISTING AND TREATMENT-EMERGENT AUTOIMMUNE CYTOPENIAS IN PATIENTS WITH CLL
This is an observational retrospective study aimed at evaluating the differential impact of Venetoclax and Venetoclax-based combination regimens on pre-existing and treatment-emergent autoimmune cytopenias in patients with CLL - CENTRAL NERVOUS SYSTEM CLL, A RARE DISEASE WITH UNCLEAR MANAGEMENT
This is a retrospective data collection on CLL patients who developed CNS disease involvement. - CD-19-CAR-T CELLS IN PATIENTS WITH RICHTER’S TRANSFORMATION (RT)
Richter’s transformation (RT) is a very aggressive lymphoma with limited treatment options. The response rate and durability of CAR-T cells in RTs is unknown. Thus, we suggest a retrospective multicenter study to identify response to CAR-T cells in RT and define proportion of patients that are referred to allogeneic transplant following CAR-T. - CLONAL RELATIONSHIP IN RICHTER TRANSFORMATION (RT)
Riccardo Moia (Novara, Italy) launched an ERIC project aiming at studying biological and clinical features of RT stratified on their clonal relationship with the preceding CLL. - CARDIAC FUNCTION ASSESSMENT IN PATIENTS WITH CLL
ERIC is conducting a survey on if and how cardiac function is assessed in patients with CLL over disease course, in particular to understand how severe cardiac impairment is affecting treatment choice at the time of progression. We would be very grateful if you would complete this very brief survey to help ERIC gather information on cardiac function assessment, its role in patient management and the potential application in the design of interventional clinical trials with targeted agents. - CLINICAL OUTCOMES OF PATIENTS WITH CLL BELONGING TO SUBSET #2
This observational retrospective study aims to study the clinical outcomes of patients with CLL belonging to subset #2, focusing on novel agents. - CLINICAL IMPORTANCE OF SATELLITE SUBSETS
This is an observational retrospective study aiming to study the clinical importance of satellite subsets to major stereotyped subsets, i.e., subsets #1,#2, and #8 in chronic lymphocytic leukemia. Major stereotyped subsets bear
striking immunogenetic similarities to some minor subsets, which have been termed satellite subsets. Typical pairs of major and satellite subsets include (i)#1 and #99; (ii) #2 and #169, and (ii) #8 and #8B. Despite the immunogenetic similarities, the clinical associations between these pairs of major and satellite subsets are largely unknown and represent the focus of this study. - IMMUNOGLOBULIN GENE SEQUENCE ANALYSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA IN THE ERA OF NGS: PROGNOSTIC IMPLICATIONS
This retrospective study will be a collaborative effort towards the detailed immunogenetic analysis of immunoglobulin gene sequence data obtained through next generation sequencing (NGS), aiming to:- explore the clinical relevance of the 98% cut-off value for IGHV gene identity to the germline for discriminating patients into U-CLL and M-CLL categories based on results obtained by NGS
- assess the clinical implications of co-existing clonotypes bearing discordant IGHV gene SHM status
- evaluate the clinical relevance of intraclonal diversification within the dominant clonotype
- search for a reliable cut-off value for distinguishing between secondary CLL-like clonal expansions, immune reactive cell clones, and the normal background’
COMPLETED+
- OBINUTUZUMAB + CHLORAMBUCIL AS FRONT-LINE TREATMENT IN CLL
- OBSERVATIONAL STUDY TO ASSESS THE EFFICACY AND SAFETY OF BENDAMUSTINE PLUS RITUXIMAB IN PATIENTS AFFECTED BY CHRONIC LYMPHOCYTIC LEUKEMI
- PROGNOSTIC AND PREDICTIVE VALUE OF COMPLEX KARYOTYPING USING CHROMOSOME BANDING ANALYSIS OR MICROARRAY-BASED PROFILING IN CLL
- COMPARATIVE ANALYSIS OF TARGET ENRICHMENT TECHNIQUES FOR THE DETECTION OF GENE MUTATIONS IN CLL
- COVID-19 SEVERITY AND MORTALITY IN PATIENTS WITH CLL
- COVID-19 SEVERITY AND MORTALITY IN PATIENTS WITH CLL: AN UPDATE OF THE INTERNATIONAL ERIC AND CAMPUS CLL STUDY
- THROMBOTIC AND BLEEDING COMPLICATIONS IN PATIENTS WITH CLL AND SEVERE COVID-19
- THE EVOLVING LANDSCAPE OF COVID-19 AND POST-COVID CONDITION IN PATIENTS WITH CLL
- OTHER MALIGNANCIES IN THE HISTORY OF CLL: AN INTERNATIONAL MULTICENTER STUDY CONDUCTED BY ERIC, THE EUROPEAN RESEARCH INITIATIVE ON CLL, IN HARMONY
- REAL-WORLD EVIDENCE ON THERAPEUTIC STRATEGIES AND TREATMENT-SEQUENCING IN PATIENTS WITH CLL
DATABASES+
- TP53 VARIANTS DATABASE IN CLL
The TP53 variants database collects the list of curated TP53 variants obtained within certified TP53 diagnostics with the aim of providing a tool to facilitate the interpretation of TP53 variants in Chronic Lymphocytic Leukemia (CLL). The main objectives of the TP53 variants database are:
[1] to create a CLL-specific database of TP53 variants, perform expert curation and interpretation, and make the molecular TP53 data available to the scientific community
[2] to determine the profile of TP53 variants detected in CLL
[3] to analyze TP53 variant profiles in the context of different clinical and biological variables in connection with data from the ERIC CLL database - ERIC CLL database
The ERIC CLL database is a data management system for the collection and organization of prospective and retrospective clinical and biological data from patients with Chronic Lymphocytic Leukemia (CLL). The main objectives of the ERIC CLL database are:
[1] to collect and transform clinically relevant RWD into evidence and correlate with biological data in order to provide accurate information about the state-of-the-art diagnosis
[2] to generate hypotheses regarding important disease characteristics, laboratory studies and therapies
[3] to define relevant parameters influencing CLL impact on health systems - ERIC IG CLL database
The ERIC CLL Immunogenetics database (CLL-DB, hosted by the International Immunogenetics Information System – IMGT) contains immunogenetic data from patients with CLL aiming to foster high-quality collaborative research on CLL and related disorders, with a main focus on understanding the biology of CLL and refining the molecular stratification of patients.
COMPLETED PROJECTS
- Identification and characterization of major stereotyped subsets in cll
- Clinical relevance of major stereotyped subsets in CLL
- Clinical significance of stereotyped subset #2
- ERIC recommendations for IG gene analysis in CLL
- Satellite stereotyped subsets and their prognostic relevance
ACTIVE PROJECTS
- Large-scale analysis of BCR stereotypy in CLL – the 100,000 cohort
- In-depth study of satellite stereotyped subsets – focus on clinical significance
- Dissecting the heterogeneity of IG-mutated CLL
- NGS Immunogenetics in the era of novel agents